منابع مشابه
Erythrocyte Glutathione Reductase By ERNEST BEUTLER AND MARY
By ERNEST BEUTLER AND MARY K. Y. Yu m T HE EXACT ROLE of reduced glutathione ( OSH ) in the economy of the red blood cell remains to be defined. Drug-induced hemolytic anemia due to glucose-6-phosphate dehydrogenase deficiency is associated with lowt and with unstable2 0S1-I. Yet, a condition has been described in which red cell glutathione is virtually absent with only mild hemolysis being obs...
متن کاملErythrocyte Glutathione Synthetase
Glutathione synthetase (GSH-S) is one of the two known hereditary causes of glutathione deficiency. We describe a family whose two children have hemolytic anemia. The children's erythrocytes lack GSH and are severely deficient in GSH-S activity. No neurologic findings or 5-oxoprolinuria were present. A concurrent deficiency of glutathione-S-transferase (GST) was also detected in the erythrocyte...
متن کاملIn vitro effects of some drugs on human erythrocyte glutathione reductase.
The effects of ketotifen, meloxicam, phenyramidol-HCl and gadopentetic acid on the enzyme activity of GR were studied using human erythrocyte glutathione reductase (GR) enzymes in vitro. The enzyme was purified 209-fold from human erythrocytes in a yield of 19% with 0.31 U/mg. The purification procedure involved the preparation of haemolysate, ammonium sulphate precipitation, 2'',5'-ADP Sepharo...
متن کاملStudies on Chromated Erythrocytes. Effect of Sodium Chromate on Erythrocyte Glutathione Reductase.
The marked affinity of erythrocytes for hexavalent chromate anion was reported in 1950 by Gray and Sterling (1). Since then, erythrocytes labeled with radioactive sodium chromate have been used extensively for the determination of erythrocyte survival in vivo (1-5) and the determination of blood volume (4-6). The anionic hexavalent form of chromium is bound firmly to erythrocytes, is not reutil...
متن کاملAmino acid sequence homology between pig heart lipoamide dehydrogenase and human erythrocyte glutathione reductase.
Extensive amino acid sequence homology has been found between nine tryptic peptides of pig heart lipoamide dehydrogenase (NADH:lipoamide oxidoreductase, EC 1.6.4.3] and the sequence of human erythrocyte glutathione reductase [NAD(P)H:glutathione oxidoreductase, EC 1.6.4.2]. The average homology is 40%. Six lipoamide dehydrogenase peptides are homologous with segments of the two parts of the FAD...
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ژورنال
عنوان ژورنال: Blood
سال: 1963
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v21.5.573.573